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Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications

The use of degradable materials is required to address current performance and functionality shortcomings from biologically-derived tissues and non-resorbable synthetic materials used for hernia mesh repair applications. Herein a series of degradable l-valine-co-l-phenylalanine poly(ester urea) (PEU) copolymers were investigated for soft-tissue repair. Poly[(1-VAL-8)0.7-co-(1-PHE-6)0.3] showed the highest uniaxial mechanical properties (332.5?±?3.5?MPa). Additionally, l-valine-co-l-phenylalanine poly(ester urea)s were blade coated on small intestine submucosa extracellular matrix (SIS-ECM) and found to enhance the burst test mechanical properties of SIS-ECM in composite films (force at break between 102.6?±?6.5–151.4?±?11.3?N). Free standing films of l-valine-co-l-phenylalanine PEUs were found to have superior extension at break when compared to SIS-ECM (averages between 1.2 and 1.9?cm and 1.2?cm respectively). Cellular spreading and proliferation were observed in vitro with a reduced inflammatory response for poly[(1-VAL-8)0.7-co-(1-PHE-6)0.3] when compared to polypropylene in an in vivo hernia rat model. These results support the use of PEU copolymers as free-standing films or as composite materials in soft-tissue applications for hernia-repair.

» Author: Nathan Z. Dreger, Zhaobo Fan, Zachary K. Zander, Chinnapatch Tantisuwanno, Molly C. Haines, Morgan Waggoner, Trenton Parsell, Claus S. Søndergaard, Michael Hiles, Christopher Premanandan, Matthew L. Becker

» Reference: 10.1016/j.biomaterials.2018.08.003

» Publication Date: 03/08/2018

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This project has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° [609149].

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