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METHOD FOR PRODUCING POLYMER COATING-BASED NITROGEN OXIDE DELIVERY COMPOSITE, AND USE OF SAME

The present invention relates to a nitrogen oxide delivery composite in which the surface of a base material such as nano-particles or the like is modified by a polymer having a secondary amine group. A secondary amine forms a diazeniumdiolate functional group through a high pressure reaction with nitrogen monoxide, and the functional group can function as a nitrogen oxide provider. According to the present invention, the surface of a base material can be modified by a polymer to be single layer or multilayer through a layer-by-layer (LbL) coating method. The production technique involves simple processes, is economical, and can be applied in a wide range of fields. In addition, the emission speed and emission amount of nitrogen monoxide can be easily adjusted, and the distribution of a base material such as nano-particles or the like can be increased. The nitrogen oxide delivery composite produced according to the present invention is not cytotoxic, and thus is expected to be usable for medical purposes, such as for enlarging blood vessels, treating wounds, or killing bacteria and the like, in vivo, through adjustment of the emission amount and emission speed of nitrogen monoxide.


» Number: WO2018080155A2 (A2)

» Publication Date: 18//2/03/0

» Applicant: CHUNG ANG UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION?[KR]

» Inventor: HONG JINKEE?[KR]; JEONG HYE JOONG?[KR]

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This project has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° [609149].

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